Alzheimer's Disease Prevention Trial

National Institutes of Health (NIH)

Status and phase: Completed; Phase 3

Conditions: Alzheimer Disease; Memory Disorders

Treatments: Drug: Estrogen; Drug: Estrogen and Progesterone

Study type: Interventional

Funder types: NIH

Identifiers

NCT00000176

IA0018

RO 1AG15922-01

Details and patient eligibility

About

This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.

Full description

PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.

Sex: Female

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy women 65 or older with a family history of memory problems not currently on estrogen.

Exclusion criteria

• Significant neurological impairment
• Current estrogen use
• History of breast cancer