Ambulatory Anesthesia and Light Therapy (LI-AMB)

University Hospital, Strasbourg, France

Status: Unknown

Conditions: Colonoscopy; Anesthesia

Treatments: Other: light therapy (1500 lux); Other: standard light (100 LUX)

Study type: Interventional

Funder types: Other

Identifiers

NCT00813345

2007-A00867-46

4057

Details and patient eligibility

About

We previously evidenced in both animal models and patients that a short duration ambulatory anesthesia impacts the circadian rest-activity biological rhythm, at least during the first 3 days. The light is the main, natural synchronisateur, of the biological cerebral clock, and is used as therapeutics in chronic disturbances of the circadian rest activity rhythm and of the sleep (Alzheimer disease for example). We would like to test for a simple and safe strategy to prevent such a long-lasting effect of anesthesia on biological clock:the increase of the light intensity at a still physiological level during the initial phase of recovery from anesthesia by using a particular artificial light of color spectrum similar to natural sun daylight.

Enrollment: 360 estimated patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I & II
• ambulatory anesthesia for colonoscopy on Monday or Tuesday
• social security

Exclusion criteria

• treatment for cancer
• hypnotics, beta-bloquers
• pregnancy
• legal supervision
• trans 5 meridian travel in the last two months

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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360 participants in 2 patient groups, including a placebo group

A - Light therapy

Experimental group

Description:

Light therapy (1500 lux)

Treatment:

Other: light therapy (1500 lux)

B - identical control lamp

Placebo Comparator group

Description:

identical control lamp

Treatment:

Other: standard light (100 LUX)