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Amino Acid Balance During Physical Inactivity

U

University of Exeter

Status

Completed

Conditions

Assessing Muscle Amino Acid Balance

Treatments

Other: Forearm immobilization
Other: High-fat overfeeding

Study type

Interventional

Funder types

Other

Identifiers

NCT02980952
157758/03

Details and patient eligibility

About

The aim is to assess the impact of physical inactivity on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding will modulate muscle amino acid balance and forearm glucose uptake.

Full description

The aim is to assess the impact of forearm cast immobilization on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding during immobilization will modulate muscle amino acid balance and forearm glucose uptake.

Enrollment

22 patients

Sex

Male

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • BMI between 18 and 30

Exclusion criteria

  • Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes).
  • Any diagnosed cardiovascular disease or hypertension.
  • Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥140 mmHg over two or more measurements and an average diastolic blood pressure of ≥90 mmHg over two or more measurements.)
  • Chronic use of any prescribed or over the counter pharmaceuticals.
  • Regular use of nutritional supplements (e.g. creatine, protein supplementation)
  • Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
  • A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
  • Any previous motor disorders.

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

22 participants in 2 patient groups, including a placebo group

Energy-balanced diet
Placebo Comparator group
Description:
Forearm immobilization whilst consuming an energy-balanced diet
Treatment:
Other: Forearm immobilization
High-fat overfeeding
Experimental group
Description:
Forearm immobilization whilst consuming a high-fat diet, 50% energy excess
Treatment:
Other: High-fat overfeeding
Other: Forearm immobilization

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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