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Amino Acid Kinetics in Blood After Consuming Different Milk Protein Supplements

N

Norwegian School of Sport Sciences

Status

Completed

Conditions

Healthy Participants

Treatments

Dietary Supplement: Whey protein concentrate 80 (WPC-80)
Dietary Supplement: Microparticulated whey
Other: Strength Training
Dietary Supplement: Hydrolyzed whey
Dietary Supplement: Native whey
Dietary Supplement: Milk 1%

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT02882386
NorwegianSSS

Details and patient eligibility

About

The aim of this study is to investigate the amino acid kinetics in blood after a bout of strength training and ingestion of different milk protein supplements (native whey, whey protein concentrate 80, hydrolysed whey, microparticulated whey and milk) The investigators hypothesize that native whey will give a faster and higher rise in blood concentrations of leucine compared to the other milk protein supplements.

Full description

Increasing or maintaining muscle mass is of great importance for populations ranging from athletes to patients and elderly. Resistance exercise and protein ingestion are two of the most potent stimulators of muscle protein synthesis. Both the physical characteristic of proteins (e.g. different digestion rates of whey and casein) and the amino acid composition, affects the potential of a certain protein to stimulate muscle protein synthesis. Given its superior ability to rapidly increase blood leucine concentrations to high levels, whey is often considered the most potent protein source to stimulate muscle protein synthesis. Native whey protein is produced by filtration of unprocessed milk. Consequently, native whey has different characteristics than WPC-80, which is exposed to heating and acidification. Because of the direct filtration of unprocessed milk, native whey is a more intact protein compared with WPC-80. Of special interest is the higher amounts of leucine in native whey.

The aim of this double-blinded randomized 5-arm cross-over study is to compare amino acid kinetics in blood after a bout of strength training and ingestion of 20 grams of high quality, but distinct, dairy protein supplements (native whey, whey protein concentrate 80, hydrolysed whey, microparticulated whey and milk). Furthermore, the investigators investigate whether differences in amino acid kinetics affect acute blood glucose and urea response, as well as recovery of muscle function after a bout of strength training.

The investigators hypothesize that native whey will give a faster and higher rise in blood concentrations of leucine compared to the other protein supplements.

Enrollment

13 patients

Sex

Male

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy in the sense that they can conduct training and testing
  • Able to understand Norwegian language written and oral

Exclusion criteria

  • Diseases or injuries contraindicating participation
  • Use of dietary supplements (e.g. proteins, vitamins and creatine)
  • Lactose intolerance
  • Allergy to milk
  • Allergy towards local anesthetics (xylocain)

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Quadruple Blind

13 participants in 5 patient groups, including a placebo group

Milk 1%
Placebo Comparator group
Description:
Participants performed a bout of strength training and consumed 636 ml of a protein supplement
Treatment:
Dietary Supplement: Milk 1%
Other: Strength Training
Whey protein concentrate 80 (WPC-80)
Experimental group
Description:
Participants performed a bout of strength training and consumed 636 ml of a protein supplement
Treatment:
Other: Strength Training
Dietary Supplement: Whey protein concentrate 80 (WPC-80)
Microparticulated whey
Experimental group
Description:
Participants performed a bout of strength training and consumed 636 ml of a protein supplement
Treatment:
Other: Strength Training
Dietary Supplement: Microparticulated whey
Hydrolyzed whey
Experimental group
Description:
Participants performed a bout of strength training and consumed 636 ml of a protein supplement
Treatment:
Other: Strength Training
Dietary Supplement: Hydrolyzed whey
Native whey
Experimental group
Description:
Participants performed a bout of strength training and consumed 636 ml of a protein supplement
Treatment:
Dietary Supplement: Native whey
Other: Strength Training

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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