Aminophylline Infusion on Pain Intensity After Ureterocopic Lithotripsy

Tanta University

Status: Completed

Conditions: Ureterocopic Lithotripsy; Aminophylline; Pain

Treatments: Other: Control group; Drug: Aminophylline group

Study type: Interventional

Funder types: Other

Identifiers

NCT05705050

36264PR19/1/23

Details and patient eligibility

About

This study will be conducted to evaluate the effect of intraoperative systemic aminophylline infusion on pain intensity in patients undergoing ureteroscopic lithotripsy surgeries with ureteric stent placement at the end of the procedure.

Enrollment: 50 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged between 18 to 50 years
• American society of anesthesiology (ASA) physical status I - II
• Body mass index (BMI) less than 30.0 kg/m2
• Scheduled for ureteroscopic lithotripsy surgery with D-J ureteric stent placement at the end of procedure
• Under general anesthesia.

Exclusion criteria

1. Patients with central nervous system diseases, cardiovascular diseases, arrhythmias, cerebrovascular diseases, convulsions, renal impairment or hepatic dysfunction.
2. Pregnancy or lactation.
3. Patients with a history of allergy to aminophylline.
4. Coffee consumption (more than 2 cups/day)
5. Patients with opioid addiction or patients treated with B agonists, tranquilizers, or antidepressants.
6. Short procedures less than 30 minutes or procedures not requiring D-J stent placement.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups, including a placebo group

Aminophylline group

Experimental group

Description:

Patients will receive 4 mg/kg aminophylline diluted in 100 ml normal saline over 20 minutes after induction of anesthesia and positioning of patients in lithotomy position.

Treatment:

Drug: Aminophylline group

Control group

Placebo Comparator group

Description:

Patients will receive 100 ml normal saline over 20 minutes after induction and lithotomy positioning.

Treatment:

Other: Control group