Aminophylline on Recovery in Functional Endoscopic Sinus Surgery Under Dexmedetomidine Hypotensive Anesthesia

Tanta University

Status: Completed

Conditions: Dexmedetomidine; Functional Endoscopic Sinus Surgery; Aminophylline

Treatments: Drug: normal saline; Drug: Aminophylline group

Study type: Interventional

Funder types: Other

Identifiers

NCT05738135

36264PR58/1/23

Details and patient eligibility

About

This study will be conducted to evaluate the effect of intravenous aminophylline on hemodynamics and recovery of patients receiving dexmedetomidine infusion during functional endoscopic sinus surgery.

Full description

Aminophylline is a nonselective adenosine receptor antagonist used for the treatment of asthma and chronic obstructive pulmonary disease. It has been used to antagonize the effects of anaesthetic and analgesic agents

Enrollment: 52 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients aged between 18 to 50 years, have American society of anesthesiology (ASA) physical status I - II and scheduled for elective FESS under general anesthesia and receiving dexmedetomidine infusion for controlled hypotension during surgery.

Exclusion criteria

1. Patients with central nervous system diseases, cardiovascular diseases, hypertension, arrhythmias, cerebrovascular diseases, convulsions, renal impairment or hepatic dysfunction.
2. Pregnancy or lactation.
3. Patients with a history of allergy to aminophylline.
4. Patients with recurrent sinus surgery, hypertension.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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52 participants in 2 patient groups, including a placebo group

Aminophylline group

Experimental group

Description:

Patients will receive 4 mg/kg aminophylline diluted in 50 ml normal saline over 30 minutes.

Treatment:

Drug: Aminophylline group

Control group

Placebo Comparator group

Description:

Patients will receive 50 ml normal saline over 30 minutes.

Treatment:

Drug: normal saline