Amitriptyline vs GON and SON Blocks in Migraine

Republic of Turkey Ministry of Health

Status: Completed

Conditions: Migraine; Headache

Treatments: Drug: Amitriptyline; Drug: Lidocaine 1% Injectable Solution

Study type: Interventional

Funder types: Other

Identifiers

NCT04750967

E-70847213-929-3410

Details and patient eligibility

About

Comparison of efficacy and safety of amitriptyline and nerve blocks

Full description

This study aims to compare the efficacy and safety of amitriptyline and nerve blocks (greater occipital nerve and supraorbital nerve)

Enrollment: 57 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with migraine according to ICHD-3

Exclusion criteria

• Being over 50 years or under 18 years
• Malignancy and other systemic diseases

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

57 participants in 2 patient groups

Active

Experimental group

Description:

Greater occipital nerve and supraorbital nerve block with 1% lidocaine once a week for first four weeks then once a month for 5 months

Treatment:

Drug: Lidocaine 1% Injectable Solution

Control

Active Comparator group

Description:

Amitriptyline 25 mg daily for 6 months

Treatment:

Drug: Amitriptyline