Amlodipine on Blood Flow of Preovulatory Follicle in Polycystic Ovarian Patients

Ahmed Fathy Ali Mohamed Ghanem

Status: Completed

Conditions: Female Infertility Associated With Anovulation

Treatments: Drug: Clomifene citrate ( clomid 50 mg ); Drug: Amlodipine

Study type: Interventional

Funder types: Other

Identifiers

NCT02544776

effect of amlodipine in pco

Details and patient eligibility

About

On the basis of the current study, amlodipine seems to be a promising drug on improving uterine, ovarian blood flow, size of pre-ovulatory follicle, midluteal progesterone level and pregnancy outcome in patients with pco.

Full description

To know if amlodipine has vasodilator effect on ovarian ar. In pco patient.

Enrollment: 60 patients

Sex: Female

Ages: 20 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Demographic features including females in age of ≥20 & ≤35, and BMI of ≤39.

• Infertility secondary to polycystic ovary , The choice of polycystic ovary patients will be according to the Rotterdam consensus workshop (Rotterdam, 2004), and the diagnosis of polycystic ovary by ultrasonography will be made according to Adams et al. criteria which are the most often cited (Adams et al., 1985).The Rotterdam criteria as follows:

  • Oligo- or anovulation.
  • Clinical and/or biochemical signs of hyper androgynism
  • The presence of polycystic ovaries on ultrasound scan. Ultrasound findings of enlarged ovaries with multiple small cysts (10-12 or more of 2-9 mm in diameter) scattered around the periphery and highly echogenic stroma

Exclusion criteria

• Including other causes of infertility diagnosed during infertility work up.
• Patients refused to participate or to continue study.
• Also, hepatic, cardiac, and hypotensive patients will be excluded from the study.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Clomifene citrate and Amlodipine

Experimental group

Description:

Amlodipine 5mg tablet and Clomifene citrate 50 mg tablet once by mouth daily at morning starting from day number 5 of menstrual cycle till day number 9.

Treatment:

Drug: Amlodipine

Drug: Clomifene citrate ( clomid 50 mg )

Clomifene citrate

Active Comparator group

Description:

Clomifene citrate 50mg and once daily at morning starting from day number 5 of menstrual cycle till day number 9

Treatment:

Drug: Clomifene citrate ( clomid 50 mg )