Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy

Federal University of São Paulo

Status: Completed

Conditions: Bullous Keratopathy

Treatments: Procedure: amniotic membrane transplantation; Procedure: anterior stromal puncture

Study type: Interventional

Funder types: Other

Identifiers

NCT00659308

cep0728/02

Details and patient eligibility

About

The purpose of this study is to determine whether amniotic membrane transplantation is as effective as anterior stromal puncture in the relief of symptomatic bullous keratopathy.

Full description

Patients with symptomatic bullous keratopathy were randomized in 2 groups and submitted to amniotic membrane transplantation or anterior stromal puncture. The follow up was made with 1, 3, 6 and 12 months. Evaluation included complete ophthalmologic exam, esthesiometry, pachymetry, impression cytology and evaluation of pain.

Enrollment: 38 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• bullous keratopathy

Exclusion criteria

• age under 18 years old
• asymptomatic bullous keratopathy
• corneal infection
• ocular hypertension

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)