AMP as a Better Delivery System of Adenosine

Vanderbilt University Medical Center

Status and phase: Terminated; Phase 1

Conditions: Ischemia

Treatments: Drug: Adenosine Mono Phosphate (AMP); Drug: Adenosine

Study type: Interventional

Funder types: Other

Identifiers

NCT00179010

030371

Details and patient eligibility

About

Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart attacks. The problem in using adenosine is that it is taken up by cells and, therefore, very little of the adenosine we give by vein or in the artery actually reaches the tissue. We propose to use AMP as a way to improve delivery of adenosine. AMP is inactive by itself, but is converted to adenosine in tissue. We hope that by giving AMP we will increase levels of adenosine in tissue. To see if this is true, we will give either adenosine or AMP into the forearm artery while we measure how much adenosine reaches the forearm tissue.

Enrollment: 13 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• Age 18-65
• Non smokers

Exclusion criteria

• Smokers
• Any chronic disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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13 participants in 2 patient groups

Adenosine then Adenosine Mono Phosphate (AMP)

Experimental group

Description:

Intrarterial infusion of adenosine then same subject switch to AMP one month apart.

Treatment:

Drug: Adenosine

Drug: Adenosine Mono Phosphate (AMP)

Adenosine Mono Phosphate (AMP) then adenosine

Experimental group

Description:

Intrarterial infusion of AMP then same subject switch to Adenosine one month apart.

Treatment:

Drug: Adenosine

Drug: Adenosine Mono Phosphate (AMP)