Amyotrophic Lateral Sclerosis: A Multicenter Retrospective Observational Registry

Biocells Medical

Status: Active, not recruiting

Conditions: Amyotrophic Lateral Sclerosis (ALS); Amyotrophic Lateral Sclerosis &Amp; Other Neuromuscular Disorders

Treatments: Biological: Imaging and Clinical Reports

Study type: Observational

Funder types: Industry

Identifiers

NCT07143656

Bio120003

Details and patient eligibility

About

This retrospective observational study will analyze de-identified clinical data from patients with amyotrophic lateral sclerosis (ALS) collected at multiple centers over 7 years. The primary objective is to describe disease progression using the ALS Functional Rating Scale-Revised (ALSFRS-R). Secondary objectives include evaluating survival, ventilatory decline, and correlations between available biomarkers (e.g., neurofilament light chain, cytokines) and disease trajectory. No new interventions or patient contact will occur.

Enrollment: 36 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Diagnosis of amyotrophic lateral sclerosis (ALS) or motor neuron disease confirmed.
2. Age ≥18 years.
3. Availability of at least one ALS Functional Rating Scale-Revised (ALSFRS-R) score.
4. Availability of longitudinal follow-up data.

Exclusion criteria

1. Patients with alternative diagnoses that mimic ALS (e.g., multifocal motor neuropathy, cervical myelopathy, myasthenia gravis).
2. Absence of medical records