Amyotrophic Lateral Sclerosis Registry

yilong Wang

Status

Not yet enrolling

Conditions

Amyotrophic Lateral Sclerosis

Treatments

Other: Amyotrophic Lateral Sclerosis

Study type

Observational

Funder types

Other

Identifiers

NCT05892822

KY2023-013-02

Details and patient eligibility

About

This study takes amyotrophic lateral sclerosis (ALS) patients as the main research object. Through collecting genetics, imaging and clinical symptoms for Exploratory research, we will construct the gene spectrum of ALS in China, explore unknown pathogenic genes, explore the characteristic image characteristics of ALS, and establish the iPSCs library of ALS, providing resources and basis for the research of pathogenesis and treatment targets of ALS.

Full description

This study is a multicenter, prospective registration study that will follow up patients with clinically confirmed and suspected amyotrophic lateral sclerosis for a period of 2 years. A total of 1000 patients will be included to dynamically observe the changes in clinical symptoms and signs, imaging, electrophysiology, biomarkers, biological samples and so on, which will construct a genetic profile of ALS in China, explore the etiology and pathogenesis, and establish an iPSCs library, provide a basis for finding treatment targets.

Enrollment

1,000 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

18 years old ≤ age ≤ 80 years old;
Patients are diagnosed definite or probable ALS according to the Awaji diagnostic criteria;
Sign an informed consent form.

Exclusion criteria