An Alternative Approach to Improve Hyperglycemia Among Type 2 Diabetes Patients

Arizona State University (ASU)

Status: Completed

Conditions: Type2 Diabetes

Treatments: Behavioral: Exercise; Dietary Supplement: Bitter melon juice (100 ml)

Study type: Interventional

Funder types: Other

Identifiers

NCT04268212

STUDY00004172

Details and patient eligibility

About

The study compared the effect of bitter melon intake and moderate exercise on postprandial glucose levels as measured by incremental area under the curve (iAUC) in eight patients with type 2 diabetes.

Full description

Background: This study compared the effects of bitter melon intake and moderate-intensity physical activity on postprandial glucose responses in type 2 diabetic patients.

Methods: A total of 8 patients with type 2 diabetes were randomly assigned to two sequences (AB, BA) with two treatments (A or B) using a 2 x 2 randomized cross-over design: A) 100 ml of bitter melon juice administered 15 minutes prior to the 75-g oral glucose load; B) 30 minutes walking at moderate-intensity performed 15 minutes after the oral glucose load.

Enrollment: 8 patients

Sex: All

Ages: 20 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• An age of 20 to 79 years
• Physician-diagnosed type 2 diabetes
• Medical clearance for physical activity from their healthcare provider

Exclusion criteria

• Pregnant or were receiving insulin treatment
• An allergy to bitter melon
• Medical conditions that impacted the normal the functioning of the gastrointestinal tract
• Contraindications to physical activity

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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8 participants in 2 patient groups

Bitter Melon

Experimental group

Description:

The participants were asked to consume 100 ml of bitter melon juice 15 minutes prior to the 75-g oral glucose intake. Participants drank the juice within 5 minutes. Participants remained seated throughout the following 2 hours.

Treatment:

Dietary Supplement: Bitter melon juice (100 ml)

Exercise

Experimental group

Description:

Participants performed 30 minutes of treadmill walking at 65% of the age-predicted maximum heart rate. The exercise started 15 minutes after the 75-g oral glucose intake.

Treatment:

Behavioral: Exercise