An Analysis of the Efficacy of a Pre-Emptive Multimodal Pain Regimen in Reducing Acute Post-Operative Pain and Narcotic Pain Medication Requirements in Spine Surgery

NYU Langone Health

Status and phase: Completed; Phase 4

Conditions: Spine Injuries and Disorders; Pain, Postoperative; Narcotic Use

Treatments: Drug: Pre-op Multimodal analgesia (MMA) regimen + standard post-op oxycodone

Study type: Interventional

Funder types: Other

Identifiers

NCT04522206

20-00734

Details and patient eligibility

About

The aim of this study is to investigate the hypothesis that multimodal pain regimen (consisting of acetaminophen, celecoxib, gabapentin, and oxycodone) administered pre-operatively before elective spine surgery significantly decreases acute pain post-operatively as well as decreasing requirements of post-op opioids for pain control in PACU as compared to patients undergoing elective spine surgery without a pre-operative pain regimen.

Enrollment: 44 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergoing elective spine surgery at NYU Winthrop
• Age over 18 years

Exclusion criteria

• History of neuromuscular disorders
• History of inflammatory arthropathies
• History of spine metastases or active cancer in spine
• Medical History including any of the following: renal dysfunction, gastric ulcers, hepatic dysfunction, coagulopathic/bleeding disorders, prior adverse or allergic reactions to any of the medications in the study
• Age less than 18 years

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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44 participants in 1 patient group

Patients undergoing elective spine surgery

Experimental group

Treatment:

Drug: Pre-op Multimodal analgesia (MMA) regimen + standard post-op oxycodone