An Analysis of Urinary Proteases as Biomarkers for Hepatocellular Carcinoma-101423

Vanderbilt University Medical Center

Status: Completed

Conditions: Hepatocellular Carcinoma; Liver Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01316679

Urinary Biomarkers 101423

Details and patient eligibility

About

Specific urine proteases or groups of these enzymes can be reliable biomarkers and an effective gauge of response to therapy in patients with hepatocellular carcinoma.

Enrollment: 87 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ability and willingness to provide written informed consent
• Must be between 18-90 years of age at the time of consent
• Ability to provide urine specimen at protocol-defined timepoints
• Must have treatment interventions planned that are directly related to liver disease (excluding those assigned to group 3-Controls)

Exclusion criteria

• Suspected inability, e.g. unwillingness to comply with study procedures or unwillingness to provide written consent

Trial design

87 participants in 3 patient groups

group A

Description:

Patients with known HCC

Group B

Description:

Patients with liver disease but no HCC

Group C

Description:

Control; patients with no known liver disease or HCC