An Anti-inflammatory Diet Effect on Metabolic, Inflammatory and Immune Status of Obese Younger Adults

Clinical Hospital Center Rijeka

Status: Completed

Conditions: Obesity

Treatments: Behavioral: Control energy-restricted diet; Behavioral: Anti-inflammatory energy-restricted diet

Study type: Interventional

Funder types: Other

Identifiers

NCT03987776

AIDIETOBESITY18-269/441

Details and patient eligibility

About

Diet has a major role in the etiology of obesity, and there is a growing body of evidence suggesting that a variety of dietary factors can modulate obesity-induced chronic low-grade inflammation and thus the course of obesity-related chronic non-communicable diseases. The present intervention study aims to evaluate the effect of an anti-inflammatory diet on weight loss, body composition, cardiometabolic risk factors and immune system response among young adults of the obese younger adults.

Full description

Obesity pandemic presents a major challenge to chronic disease prevention worldwide. A low-grade chronic inflammation is associated with obesity and related cardiometabolic disorders, such as cardiovascular diseases, type 2 diabetes and some type of cancers. Diet has a major role in the etiology of obesity, and there is a growing body of evidence suggesting that a variety of dietary factors can modulate obesity-induced chronic low-grade inflammation and thus the course of obesity-related chronic non-communicable diseases. The present intervention study aims to evaluate the effect of an anti-Inflammatory diet on weight loss, body composition, cardiometabolic risk factors and immune system response among younger adults. A nutritional intervention based on an energy-restricted anti-inflammatory diet will be compared with an isocaloric standard diet (55-60% carbohydrates, 25% fat, 15-20% protein). The inflammatory potential of the diet will be assessed with the Dietary Inflammatory Index®.

Enrollment: 220 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adults age of 18 to 50 years
• body mass index ≥ 30 kg/m2
• with or without obesity related complications

Exclusion criteria

• smoking
• chronic hearth, renal and/or liver diseases,
• active carcinoma or having carcinoma in last year
• anti-inflammatory and/or immunosuppressive drugs intake
• changing the existing medication therapy
• persons older than 50 years
• active infection and/or surgical procedure in last 3 months
• nutritive allergy or intolerance to any anti-inflammatory diet constituent
• pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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220 participants in 2 patient groups

Anti-inflammatory diet

Experimental group

Description:

energy-reduced diet with the use of low glycemic foods, wholegrain products, legumes, colorful vegetables and fruit, nuts, seeds, marine fish, olive oil, green/black tea, and multiple spices and herbs

Treatment:

Behavioral: Anti-inflammatory energy-restricted diet

Control energy-resticted diet

Experimental group

Description:

isocaloric to anti-inflammatory diet, energy restricted diet (55-60% carbohydrates, 25% fat, 15-20% protein) used in a standard obesity management

Treatment:

Behavioral: Control energy-restricted diet