An Assessment of Intra-lesional 3% Polidocanol Solution in the Treatment of Digital Myxoid Cyst

University of Edinburgh

Status and phase: Terminated; Phase 4

Conditions: Ganglion Cysts

Treatments: Drug: polidocanol; Procedure: infra-red coagulation; Procedure: cryotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT02154789

2013-005338-39

Details and patient eligibility

About

Digital myxoid cysts arise from degeneration in the connective tissue of the digit joint, usually the last joint of the finger or toe, often due to underlying joint arthritis. They may connect with the joint. Pressure from the cyst can result in deformity of the digit's nail and trauma to the cyst results in leakage of the fluid, representing a potential source of entry for infection. Cysts can be tender and interfere with the digit's function. A variety of treatments are available, from simple extrusion which is rarely successful, to more destructive cryotherapy, infra-red coagulation and formal excision under local anaesthetic. These latter three approaches can result in considerable scarring. Sclerosant injection of polidocanol in one small non-randomised trial has been reported to be a well tolerated efficacious treatment with minimal scarring and long-term resolution. Following a pilot study, the investigators aim to trial this treatment to assess efficacy in a larger population.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All patients referred to dermatology in NHS Lothian or NHS Fife who have a visible Digital Myxoid Cyst affective the dital phalynx of the toes or fingers.
• The patient must have the ability to give informed consent

Exclusion criteria

• History of sensitivity to polidocanol or other sclerosants
• Age less than 18
• Inability to give informed consent
• Inability to report side effects experienced
• Cyst not clearly visible
• Cyst not fluid-filled

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 3 patient groups

polidocanol

Experimental group

Treatment:

Drug: polidocanol

cryotherapy

Active Comparator group

Treatment:

Procedure: cryotherapy

infra-red coagulation

Active Comparator group

Treatment:

Procedure: infra-red coagulation