An Assessment of Pulse Pressure Variation to Guide Fluid Therapy in Cardiac Surgery Patients

Austin Health

Status and phase: Completed; Phase 2

Conditions: Cardiac Surgery

Treatments: Other: IV fluid according to PPV; Other: fluids according to standard care

Study type: Interventional

Funder types: Other

Identifiers

NCT01681758

AICU2012-007

Details and patient eligibility

About

We aim to test the hypothesis that fluid therapy based on pulse pressure variation (PPV) in patients after cardiac surgery who are mechanically ventilated leads to a significant decrease in the amount of fluid given to such patients in the first 24 hours after surgery

Full description

1. The investigators will study patients after cardiac surgery
2. The investigators will collect data on standard care in pre-intervention population
3. The investigators will collect demographic and clinical data
4. The investigators will collect biochemical data in the first 24 hours after surgery
5. The investigators will collect biochemical, physiological and clinical outcome data
6. The investigators will compare the standard care and intervention period data

Enrollment: 104 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. immediately after ICU admission after cardiac surgery
2. mandatory mechanical ventilation -

Exclusion criteria

1. Pressure support ventilation
2. ECMO
3. Intra-aortic balloon counterpulsation

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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104 participants in 2 patient groups, including a placebo group

PPV

Active Comparator group

Description:

use PPV to guide fluid therapy

Treatment:

Other: IV fluid according to PPV

standard care

Placebo Comparator group

Description:

fluids according to standard care

Treatment:

Other: fluids according to standard care