An Assistant Model for Anti-VEGF Therapy Decision
Status
Conditions
Treatments
Details and patient eligibility
About
We present FM-VEGF-CDSS system, the first foundation model-based AI system specifically designed for the decision of anti-VEGF therapy by emulating clinician decision-making reasoning process for those with exudative retinal diseases. FM-VEGF-CDSS is capable of processing multimodal input including optical coherence tomography (OCT) and descriptive medical metadata. Trained and validated on cases from centers across China, the system performed well in both internal and external validation dataset, and could generate the convenient report to enhance decision-making interpretability. To validate its clinical practice, we conducted a prospective multicenter RCT, rigorously assessing FM-VEGF-CDSS system's prediction accuracy and real-world utility. This will improve the standardized decision for anti-VEGF therapy, promoting health equity.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Presenting with clinical features suggestive of exudative retinal diseases based on the initial assessment by the physician
Exclusion criteria
- Refusal to undergo OCT testing; Refusal to complete the 6-month follow-up period; Screening for a history of intraocular surgery in both eyes within the past 6 months; Subjects with severe systemic diseases, intellectual developmental disorders, psychiatric illnesses, etc.
Patient data that the investigator deems necessary to exclude.
Trial design
Primary purpose
Allocation
Interventional model
Masking
160 participants in 2 patient groups
Trial contacts and locations
Loading...
Central trial contact
Huixun Jia, PhD; Xiaodong Prof. Sun, PhD
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal