An Early Enteral Nutrition Protocol in Shanghai

Shanghai Jiao Tong University

Status: Unknown

Conditions: Critical Illness; Enteral Feeding Intolerance

Treatments: Other: Standard care; Other: Protocol care

Study type: Interventional

Funder types: Other

Identifiers

NCT03216993

Shanghai EEN

Details and patient eligibility

About

compare different enteral nutrition strategy in patients with mechanical ventilation

Full description

There has been many evidence that deficiency in energy and protein take-in are associated with poor outcome in critical patients. To reach an adequate amount of energy and protein is critical in patients with respiratory failure and with mechanical ventilation, as it prevents muscle dystrophy and thus prevents ICU acquired weakness, leading to a better outcome in the end. Enteral Nutrition is preferred as it prevents gut dysfunction in respiratory failure patients, and may prevent further infection. But there are many challenge in implement a good enteral nutrition therapy, and energy or protein deficiency is common in patient with respiratory failure. There have been many protocols aiming at reaching enough enteral nutrition for ICU patients, most of which are based on a background of western and developed countries. The investigators developped a enteral nutrition protocol based on an unique cultural background of eastern developing country, trying to help the ICU patients reaching nutrition target, so that the patients may have better outcome.

Enrollment: 400 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ICU patients
• Receiving mechanical ventilation (MV) both Non-invasive ventilation and invasive ventilation
• Expecting MV more than 72 hours

Exclusion criteria

• Pregnancy
• ICU stay < 72hr

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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400 participants in 2 patient groups

Standard care

Other group

Description:

Standard care: patients receive enteral nutrition in accordance with the usual practice in the participating units

Treatment:

Other: Standard care

Protocol care

Experimental group

Description:

Protocol care： patient receive enteral nutrition in accordance with enteral nutrition protocol studied

Treatment:

Other: Protocol care