An Evaluation of Clotting Factor Activity Before and After Total Hip Arthroplasty (CloFaTHA)

Military Institute od Medicine National Research Institute

Status: Completed

Conditions: Arthroplasty, Replacement; Coagulation Factors

Treatments: Diagnostic Test: analysis of the concentration of the clotting factors in patients who underwent primary hip arthroplasty

Study type: Observational

Funder types: Other

Identifiers

NCT04372173

681006-7

Details and patient eligibility

About

The objective of the study was to analyze both the concentration and the activity of the clotting factors, D-dimer levels, as well as fibrinogen concentration in patients who underwent primary total hip arthroplasty due to idiopathic arthrosis.

Blood loss is often related to perioperative period and may result in decrease of concentration of coagulation factors, which in turn may lead to increased bleeding. We analyzed data of thirty patients scheduled for primary hip arthroplasty: the activity of clotting factors II, VIII, X, as well as fibrinogen concentration in the following time points: (i) before surgery, (ii) six hours after the procedure, and (iii) two, (iv) four, and (v) six days after the operation. All laboratory tests were performed using automatic analyzer. At the same time intervals, an immunoenzymatic assay was used to determine D-dimer levels.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients qualified for primary hip arthroplasty for idiopathic osteoarthritis

Exclusion criteria

• hip osteoarthritis because of non-idiopathic etiology
• history of venous thromboembolism or arterial embolism
• anticoagulation treatment,
• coagulopathy
• infection, and
• renal failure defined as a creatinine clearance below 50 ml/minute.