An Evaluation Of The Novel TRAMINER Sequence By Comparison To Late Gadolinium Enhancement Images

Wake Forest University (WFU)

Status: Completed

Conditions: Myocardial Fibrosis; Cardiovascular Disease

Treatments: Other: Traminer MRI Sequence

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02727725

AHC IRB 5886

Details and patient eligibility

About

• The purpose of this study is to show that the novel TRAMINER (T(Rho) and Magnetization Transfer and Inversion Recovery) sequence provides at least as good visualization and detection of sub-endocardial scarring, fibrosis, and acute infarction as the current gold standard Inversion Recovery (IR) Turbo-Flash sequence.
• The hypothesis is that the TRAMINER sequence has the same or higher sensitivity in detecting small sub-endocardial scarring than the inversion recovery segmented gradient echo sequence known as IR-Turbo Fast low angle shot (IR Turbo-Flash), which is the accepted current gold standard for the detection of myocardial viability.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults ≥18 years of age referred for a cardiac MRI with Gadolinium enhancement only at Advocate Lutheran General Hospital

Exclusion criteria

• <18 years old,
• Adults unable to consent
• Adults for whom the MRI has not been previously scheduled
• Adults with an order for any MRI other than cardiac MRI with Gadolinium enhancement

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

Traminer MRI Sequence

Experimental group

Description:

The TRAMINER MRI sequence implementation to be tested allows the acquisition of high resolution MR images in the free-breathing patient, by combining multiple averages and motion correction with the TRAMINER preparation.

Treatment:

Other: Traminer MRI Sequence