An Exploration of the Relationship Between Serum Cytokine Levels and the Clinical Efficacy of Vedolizumab

Second Affiliated Hospital of Wenzhou Medical University

Status: Completed

Conditions: Ulcerative Colitis (UC)

Study type: Observational

Funder types: Other

Identifiers

NCT06855862

SAHoWMU-CR2025-01-207

Details and patient eligibility

About

It is uncertain the relationship between serum cytokine levels and the clinical efficacy of vedolizumab in the treatment of ulcerative colitis. The effects of cytokines on the efficacy of vidrecizumab in Chinese UC patients were retrospectively analyzed. Methods: Patients with UC were recorded. These patients were detected the levels of cytokines.

Enrollment: 105 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• UC patients Treated with Vedolizumab

Exclusion criteria

• pregnant
• had cognitive/developmental disorders that affected their ability to complete the study procedures
• had medical illness or therapies potentially affecting bone, nutrition or growth status

Trial design

105 participants in 2 patient groups

clinical remission group

Description:

partial Mayo score ≤2 points and no subscore \>1 point at week 16

non-clinical remission group

Description:

partial Mayo score \>2 points at week 16