An Exploratory Clinical Study on the Protective Effect of Cycling on the Ankle Joint in Gout

Zhu Xiaoxia

Status

Not yet enrolling

Conditions

Gout Arthritis

Physical Activity

Cycling

Treatments

Behavioral: Jogging

Behavioral: Cycling

Drug: Urate-lowering therapy (ULT)

Study type

Interventional

Funder types

Other

Identifiers

NCT07312396

KY2025-872

Details and patient eligibility

About

This study divided the enrolled gout patients into a jogging group and a cycling group to investigate 1）the effectiveness of cycling intervention in reducing the recurrence risk of gouty ankle arthritis compared with jogging. 2) To clarify the influence of different exercise patterns on the ultrasonic manifestations of gouty ankle arthritis; 3) Clarify the impact of different exercise methods on the blood uric acid levels of gout patients;

Enrollment

90 estimated patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

meets the diagnostic criteria for gout of the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) in 2015
There have been two histories of gout attacks on either side of the ankle joint in the past six months
Ultrasound examination within the past 6 months indicated that either ankle joint had characteristic ultrasound manifestations (double-track sign, and/or hyperechoic aggregates, and/or tophi, and/or bone destruction)
Those who have had an interval of at least 4 weeks since the most recent acute gout attack
If the patient is undergoing uric acid-lowering drug treatment, the drug dosage must remain stable for more than 4 weeks. During the study period, the uric acid-lowering drug regimen or dosage will not be adjusted
For women who have the potential to become pregnant, a pregnancy test must be negative, they must not be in the lactation period, and it must be confirmed that they are receiving contraception approved by the researcher and agree to maintain this contraceptive measure throughout the study process
Those who were informed of this study and signed the informed consent form

Exclusion criteria

Those who have received intra-articular injections of corticosteroids during an attack within the past three months; Those who have taken colchicine, NSAIDs, glucocorticoids in the past two weeks, or those who need to maintain anti-inflammatory drug treatment for a long time during the follow-up period
Joint trauma or other types of arthritis
There is a history of joint prosthesis or joint surgery
Those who have had acute gout attacks within 4 weeks
Patients with secondary gout caused by kidney diseases, blood disorders, or taking certain medications, radiotherapy and chemotherapy for tumors, etc
Those with severe and unstable cardiovascular and cerebrovascular diseases (such as unstable angina pectoris, coronary angiogenesis, cerebral angiogenesis, transient ischemic attack, congestive heart failure, etc.) and other diseases that researchers have determined to be acute and difficult to control