An Exploratory Open Label Study of Adjunctive L-lysine Treatment in Patients With Schizophrenia

G

Göteborg University

Status

Completed

Conditions

Schizophrenia

Treatments

Drug: L-lysine

Study type

Interventional

Funder types

Other

Identifiers

NCT00996242
LYSINE1
07TGS-1049

Details and patient eligibility

About

The objective of the present study was to investigate the possibility of using L-lysine, an amino acid that occurs naturally in food and which interferes with nitric oxide (NO) production, for the treatment of schizophrenia. L-lysine, 6 g/day, was administered to ten patients with schizophrenia as an add-on treatment to conventional antipsychotic treatment. The study was designed as a single-blinded, cross-over study where patients were randomly assigned to initial treatment with either L-lysine or placebo and screened at baseline, after four weeks when treatment was crossed over, and after eight weeks when treatment was terminated. The four-week L-lysine treatment regimen caused a significant increased in blood concentration of the amino acid and was tolerated well. The analysis of outcome measures showed a significant decrease in symptom severity as measured by the Positive and Negative Syndrome Scale (PANSS). Furthermore, the patient's ability to solve the Wisconsin Card Sorting Task (WCST) was significantly improved indicating increased problem solving capacity and cognitive flexibility. Subjective reports from three of the patients also indicated decreased symptom severity and enhanced cognitive functioning. In summary, these findings suggest potential beneficial effects of L-lysine treatment on symptom severity and cognitive deficits in patients with schizophrenia.

Enrollment

10 patients

Sex

All

Ages

23 to 56 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • a stable phase of illness
  • a stable dose of antipsychotic medication
  • no other major medical conditions or other psychiatric diagnosis
  • normal admission laboratory tests and vital signs

Exclusion criteria

substance abuse, apart from smoking

Trial design

10 participants in 1 patient group

L-lysine
Experimental group
Treatment:
Drug: L-lysine

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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