An Extension Study of Maralixibat in Patients With Progressive Familial Intrahepatic Cholestasis (PFIC)

Mirum Pharmaceuticals

Status and phase: Active, not recruiting; Phase 3

Conditions: Progressive Familial Intrahepatic Cholestasis (PFIC)

Treatments: Drug: Maralixibat

Study type: Interventional

Funder types: Industry

Identifiers

NCT04185363

MRX-503

Details and patient eligibility

About

The primary objective of this open label extension study is to evaluate the long-term safety and tolerability of maralixibat.

Full description

The study will be conducted at multiple sites in North America, Europe, Asia, and South America.

Enrollment: 90 patients

Sex: All

Ages: 1 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Key Inclusion Criteria:

1. Provide informed consent and assent (as applicable) per Institutional Review Board/Ethics Committee (IRB/EC)
2. Completion of study MRX-502

Exclusion Criteria:

1. Any female who is pregnant or lactating or who is planning to become pregnant
2. Administration of prohibited medication between the MRX-502 EOT visit and the MRX 503 Baseline Visit (Day 0)
3. History of non-compliance in study MRX-502, non-adherence to medical regimens, unreliability, mental instability or incompetence that could compromise the validity of informed consent or lead to non-adherence with the study protocol based on Investigator judgment
4. Experienced an adverse event (AE) or serious adverse event (SAE) related to maralixibat during the MRX-502 study that led to permanent discontinuation of the subject from maralixibat
5. Any other conditions or laboratory abnormalities that, in the opinion of the Investigator or Sponsor Medical Monitor, may compromise the safety of the subject, or interfere with the subject participating in or completing the study

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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90 participants in 1 patient group

Maralixibat

Experimental group

Description:

All subjects will receive Maralixibat oral solution

Treatment:

Drug: Maralixibat