An Extension Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia

BioMarin Pharmaceutical

Status and phase

Active, not recruiting

Phase 3

Conditions

Achondroplasia

Treatments

Drug: BMN 111

Study type

Interventional

Funder types

Industry

Identifiers

111-302

2017-002404-28 (EudraCT Number)

Details and patient eligibility

About

The intent and design of this Phase 3 study is to assess BMN 111 as a therapeutic option for the treatment of children with Achondroplasia

Enrollment

119 patients

Sex

All

Ages

6+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Must have completed Study 111-301
Female >= 10 years old or who have begun menses must have a negative pregnancy test at the Baseline Visit and be willing to have additional pregnancy tests during the study
If sexually active, willing to use a highly effective method of contraception while participating in the study
Are willing and able to perform all study procedures
Parent(s) or guardian(s) are willing and able to provide written, signed informed consent after the nature of the study has been explained and prior to performance of any research-related procedure. Also, subjects under the age of majority are willing and able to provide written assent (if required by local regulations or the IRB/IEC) after the nature of the study has been explained and prior to performance of any research-related procedure. Subjects who reach the age of majority in their country while the study is ongoing will be asked to provide their own written consent again upon reaching the legal age of majority.

Exclusion criteria

Permanently discontinued BMN 111 or placebo prior to completion of the 111-301 study
Have a clinically significant finding or arrhythmia on Baseline ECG that indicates abnormal cardiac function
Evidence of decreased growth velocity (<1.5 cm/year) as assessed over a period of at least 6 months or of growth plate closure (proximal tibia, distal femur) through bilateral lower extremity X-rays.
Require any investigational agent prior to completion of study period
Current therapy with medications known to alter renal function
Pregnant or breastfeeding or plan to become pregnant during study
Concurrent disease or condition that, in the view of the investigator, would interfere with study participation or safety evaluations, for any reason.
Have a condition or circumstance that, in the view of the investigator, places the subject at high risk for poor treatment compliance or for not completing the study.