An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence

University of Southern California

Status: Enrolling

Conditions: Head and Neck Carcinoma

Treatments: Other: Non-Interventional Study

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT06420219

NCI-2024-01559 (Registry Identifier)

P30CA014089 (U.S. NIH Grant/Contract)

7H-23-4 (Other Identifier)

Details and patient eligibility

About

This study evaluates the cell and biomarkers associated with the aggressive behavior of cancer.

Full description

PRIMARY OBJECTIVE:

I. High-resolution single-cell profiling of Cancer-associated fibroblasts (CAFs) in Human papillomavirus (HPV)+ Oropharyngeal Squamous Cell Carcinoma (OPSCC) and metastatic lymph nodes.

OUTLINE: This is an observational study.

Patients undergo photography, blood sample collection, tissue collection and have their medical records reviewed on study.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis/disease status: New diagnosis of head and neck cancer
• Allowable type and amount of prior therapy: No prior treatment
• Age ≥ 18 years.
• Ability to understand and the willingness to sign a written informed consent.

Exclusion criteria

• Patients who have had treatment of head and neck cancer

Trial design

50 participants in 1 patient group

Observational

Description:

Patients undergo photography, blood sample collection, tissue collection and have their medical records reviewed on study.

Treatment:

Other: Non-Interventional Study