An Iodine Balance Study to Investigate the Recommended Iodine Intake in an Elderly Population

Wenxing Guo

Status: Enrolling

Conditions: Nutrition, Healthy

Treatments: Behavioral: Restrict subjects' intake of iodine-containing foods

Study type: Interventional

Funder types: Other

Identifiers

NCT06218043

82204041-NSFC

Details and patient eligibility

About

Current Chinese dietary iodine reference intake (DRIs) standards lack direct data on recommended iodine intake (RNI) in the elderly. The elderly have a high prevalence of thyroid diseases. The risk threshold of iodine intake in the elderly is unknown. Identifying the appropriate iodine intake for the elderly to maintain optimal thyroid function to reduce the burden on medical resources is a public health issue requiring high attention. The iodine balance study is an important method for exploring physiological iodine requirements. Few iodine balance studies have been conducted in the elderly. This study aimed to conduct an iodine balance study and provide information on the appropriate iodine intake level for elderly people.

Full description

The investigators measured subjects' food and water intake throughout the day using weighing methods, and collected all urine and fecal samples. Food, drinking water, fecal and urine samples were taken to determine iodine concentrations. Each subject was required to participate in two phases of iodine balance studies. Each stage lasts 4 to 10 days. There was no intervention in the first half of the experiment, and there was an intervention of iodized salt/non-iodized salt consumption in the second half of the experiment. The appropriate level of iodine intake for the elderly was explored by fitting and analyzing the dose change relationship between iodine intake and iodine excretion.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

The target population of this study is elderly people over 60 years old. Adults living in the same household can also participate.

Inclusion Criteria:

1. aged 18 and above;
2. at least 5 years of local residence.

Exclusion Criteria:

1. family genetic diseases；
2. special dietary habits；
3. taking iodine-containing drugs or supplements；
4. metabolic diseases;
5. thyroid diseases.

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Sequential Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Iodine intake intervention balance experiment

Other group

Description:

Replace subjects' iodized salt with non-iodized salt.

Treatment:

Behavioral: Restrict subjects' intake of iodine-containing foods