An Observational Study of Cisatracurium 0.15 mg/kg in Young and Elderly (≥ 80 Years) Patients.

Matias Vested

Status: Completed

Conditions: Duration of Action of Cisatracurium; Intubation Conditions; Onset Time of Cisatracurium

Treatments: Drug: Cisatracurium

Study type: Observational

Funder types: Other

Identifiers

NCT04921735

Cisatracurium 2021

Details and patient eligibility

About

The aim of this study is to determine the onset time, duration of action and effect on intubation conditions of cisatracurium 0.15 mg/kg in elderly patients with age ≥ 80 years and in young patients aged 18 - 40 years.

Full description

The aim of this study is to determine the onset time, duration of action and effect on intubation conditions of cisatracurium 0.15 mg/kg in elderly patients with age ≥ 80 years and in young patients aged 18 - 40 years. The hypothesis of this study is that cisatracurium administered in elderly patients (>80 years) has a longer onset time and duration of action compared to younger patients.

Enrollment: 60 patients

Sex: All

Ages: 18 to 110 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients ≥ 80 or ≥18 - ≤40 years of age
2. Informed consent
3. Scheduled for elective surgery under general anaesthesia (expected duration of anaesthesia > 1 hour) with intubation and use of cisatracurium
4. American Society of Anaesthesiologists (ASA) physical status classification I to III
5. Can read and understand Danish

Exclusion criteria

1. Known allergy to cisatracurium
2. Neuromuscular disease
3. Indication for rapid sequence induction
4. Surgery in the prone position

Trial design

60 participants in 2 patient groups

Elderly

Description:

patients aged 80 years or older

Treatment:

Drug: Cisatracurium

young

Description:

patients aged 18-40 years

Treatment:

Drug: Cisatracurium