An Observational Study of Statin Treatment Induced HDL Changes (SIRIUS)

AstraZeneca

Status: Completed

Conditions: Cardiovascular Disease

Study type: Observational

Funder types: Industry

Identifiers

NCT01551784

NIS-CSE-CRE-2011/1

Details and patient eligibility

About

The aim with this study is to investigate the effect of statin induced changes in HDL-C on all cause mortality and CVD with adjustment for changes in other blood lipids and clinical parameters in Sweden, UK and the Netherlands.

Full description

An observational study of statin treatment induced HDL changes - effect on cardiovascular disease

Enrollment: 120,000 patients

Sex: All

Ages: 18 to 86 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Started treatment with statins within the observation period (2004-2010)
• The patient must have valid baseline and follow-up measurements for HDL-C and LDL-C.

Exclusion criteria

• Malignancy Alcohol abuse/alcohol dependence

Trial design

120,000 participants in 1 patient group

1