An Observational Study on the Natural Course of Chronic Pancreatitis

Naval Military Medical University

Status: Active, not recruiting

Conditions: Genetic Mutation; Chronic Pancreatitis; Drinking, Alcohol; Smoking, Tobacco

Treatments: Behavioral: smoking and alcohol assumption; Diagnostic Test: genetic sequencing

Study type: Observational

Funder types: Other

Identifiers

NCT04574297

CP-2011

Details and patient eligibility

About

To explore the impact on genetic and environmental factors for clinical manifestation, and the progression of chronic pancreatitis, including development of pancreatic insufficiency and other complications.

Full description

The present study was an observational study aimed to explore the impact of genetic factors (rare pathogenic variants of CP) and environmental factors(smoking and alcohol assumption) on the clinical manifestation and progression of CP. The observation items included the pain patterns, incidence of complications of CP, pancreatic cancer and death.

Enrollment: 798 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with a diagnosis of chronic pancreatitis
• agree to join the study and provide informed consent

Exclusion criteria

• autoimmune pancreatitis
• pancreatic cancer diagnosed within 2 years after the diagnosis of chronic pancreatitis
• the follow-up time less than 2 years
• patients presenting with diabetes and/or steatorrhea at onset of CP.

Trial design