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An Open-label Study on the Clinical Efficacy of rTMS Intervention in PD

A

Anhui Medical University

Status

Enrolling

Conditions

Supplementary Motor Area
Parkinson Disease
Transcranial Magnetic Stimulation

Treatments

Other: transcranial magnetic stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT06542991
PD-OPEN

Details and patient eligibility

About

To demonstrate that intervention targeting the supplementary motor area (SMA) using precise navigation positioning can effectively improve motor symptoms in patients with Parkinson's disease.

Full description

As an innovative non-invasive neuromodulation technology, repetitive transcranial magnetic stimulation (rTMS) has demonstrated efficacy in improving motor symptoms in patients with Parkinson's disease (PD). The supplementary motor area (SMA) has been identified as a brain region significantly associated with motor symptoms in PD patients. However, no large-sample clinical studies have yet established the clinical efficacy of rTMS, guided by neuroimaging navigation, targeting the SMA in patients with Parkinson's disease.

We describe a open-lable study designed to recruit 20 patients with idiopathic Parkinson's disease. Participants will be randomly assigned to receive either real stimulation or sham stimulation, with the left SMA undergoing 7 days of continuous theta burst stimulation (cTBS). The primary outcome measure is the change in the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III scores from baseline to post-treatment and follow-up. Secondary outcomes include changes in scores on other clinical symptom scales.

Enrollment

20 estimated patients

Sex

All

Ages

40+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Age ≥40 years old
  2. Meet Movement Disorder Society standards;
  3. Have no history of drug adjustment within 4 weeks before and during treatment;
  4. The MDS-UPDRS Ⅲ score ≥8, and the Hoehn-Yahr rating is 1-4
  5. MMSE ≥24,able to cooperate with the completion of behavioral tests and transcranial magnetic stimulation therapy.

Exclusion criteria

  1. Head MRI/CT ruled out focal brain injury or severe leukoencephalopathy (Fazekas grade 3);
  2. Various secondary parkinsonism syndromes (vascular parkinsonism, Parkinsonism combined with parkinsonism, drug parkinsonism, etc.);
  3. Severe craniocerebral trauma, received craniocerebral surgery or deep brain stimulation treatment;
  4. There are ferromagnetic implants in the body, such as cochlear implants, cardiac pacemakers, etc.
  5. The person or first-degree relatives have a history of epilepsy, unexplained loss of consciousness, or are taking anticonvulsant drugs to treat epileptic seizures;
  6. Diagnosed with a neuropsychiatric disorder other than PD
  7. Have a history of drug abuse or drug use;
  8. Participants in any clinical trial within the previous 6 month;
  9. Pregnant/lactating women or subjects (including men) who have a birth plan within 6 months;
  10. Other conditions deemed unsuitable for inclusion by the investigator.

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

20 participants in 1 patient group

rTMS group
Experimental group
Description:
On the basis of drug treatment, a course of TBS treatment is performed for 7 days.
Treatment:
Other: transcranial magnetic stimulation

Trial contacts and locations

1

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Central trial contact

Kai Wang, Ph.D.; Panpan Hu, M.D.

Data sourced from clinicaltrials.gov

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