An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study

Hospital for Special Surgery (HSS)

Status

Completed

Conditions

Carpometacarpal Osteoarthritis

Treatments

Device: Synvisc (hylan G-F20)

Study type

Interventional

Funder types

Other

Industry

NIH

Identifiers

NCT00198029

23034

101584

Grant# K23AR050607-01

Details and patient eligibility

About

The purpose of this study is to find out if hyaluronan, an injectable medication for knee arthritis, also works for arthritis at the base of the thumb. This study will also evaluate how good ultrasound is at visualizing medication in the thumb joint. We are no longer recruiting for this part of the open label trial.

Enrollment

32 patients

Sex

All

Ages

45 to 95 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Radiographic evidence of at least moderate narrowing (joint space < 1mm) or the presence of osteophytes or sclerosis at the Carpometacarpal joint
Patient complaint of unacceptable pain despite modification of activity, a trial of splinting and a therapeutic dose of NSAIDS
If bilateral disease, only the most severely involved hand, (as defined by VAS for pain), will be entered in the study.
Proficiency in English.

Exclusion criteria

Previous bad injury to the thumb
Previous hand surgery on the study thumb
Known hand comorbidities (i.e. carpal tunnel syndrome, de Quervains Tenosynovitis etc)
Rheumatoid arthritis or lupus
Bleeding problems
Being on blood thinners (except aspirin)
Known allergies to any of the medications being used
Allergies to chicken products
Current use of oral steroids
Cancer that is not cured or in remission
Severe diabetes
A serious infection somewhere else in the subject's body