An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients With Schizophrenia

Chiba University

Status and phase

Completed

Phase 2

Conditions

Schizophrenia

Treatments

Dietary Supplement: Sulforaphane-rich Broccoli Sprout Extract

Study type

Interventional

Funder types

Other

Identifiers

NCT01716858

Chiba_SFN_Openstudy2012

Details and patient eligibility

About

Accumulating evidence suggests a role of oxidative stress in the pathophysiology of schizophrenia. The potent antioxidant sulforaphane (SFN) is an organosulfur compound derived from a glucosinolate precursor found in cruciferous vegetables such as broccoli, Brussels sprouts and cabbage. The protection afforded by SFN is thought to be mediated via activation of the NF-E2-related factor-2 (Nrf2) pathway and subsequent up-regulation of phase II detoxification enzymes and antioxidant proteins, through an enhancer sequence referred to as the electrophilic responsive element or antioxidant responsive element. Recently, we reported that SFN could attenuate behavioral abnormalities in mice after the NMDA receptor antagonist phencyclidine. Considering the potent antioxidant effects of SFN, we have a hypothesis that SFN would be a potential therapeutic drug for schizophrenia. The purpose of this study is to determine whether SFN-rich broccoli sprout extract have beneficial effects in patients with schizophrenia.

Enrollment

10 estimated patients

Sex

All

Ages

20 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Schizophrenia for DSM-IV TR criteria
Patients are treated with an antipsychotic drug (risperidone, olanzapine, quetiapine, perospirone, aripiprazole, blonanserin, paliperidone).
Patients are stable for 4-weeks for antipsychotic medication.

Exclusion criteria