An Open Trial of Allopurinol in Patients With Poorly Responsive Schizophrenia

Bronx Psychiatric Center

Status: Completed

Conditions: Schizophrenia

Treatments: Drug: Allopurinal

Study type: Interventional

Funder types: Other

Identifiers

NCT00823199

ICFV12/02

Details and patient eligibility

About

This is a four week open label trial of ALLOPURINOL to the treatment regime of ten (10) poorly responsive patients with schizophrenia, monitoring their response and side-effects. No change in medication is required.

Enrollment: 10 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects with schizophrenia and poor response (no prospect of discharge because of symptoms)

Exclusion criteria

• Over 65
• Renal or liver disease
• Diabetes
• Hypertension
• Taking thiazides or ACE inhibitors

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Allopurinal treatment

Experimental group

Description:

Allopurinal 300mg once daily by mouth for four weeks

Treatment:

Drug: Allopurinal