Anaesthetic and Pediatric Living Related Liver Transplantation

Tianjin First Central Hospital

Status: Unknown

Conditions: Liver Transplantation; Children

Treatments: Drug: Sevoflurane; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT03024840

2016N0039KY

Details and patient eligibility

About

To study the effect of different anaesthetic methods on pediatric neurocognitive development and cerebral injury during pediatric living related liver transplantation .

Full description

Since the 1960 s, with the successful development of liver transplantation, it has become an important method for the treatment of patients with end-stage liver disease.Biliary atresia1 is the most frequent causes of pediatric end-stage liver disease,.The morbidity of congenital biliary atresia is 1/8000-18, 0002 ,which influence the patients' overall growth and development situation. The rising of living donor liver transplantation has provide children with the chance of a timely treatment since the 1980 s, It is no doubt that pediatric liver transplantation is facing with many complications, including the most importance of neurocognitive development .Now the researches of neurological complications is less .According to statistics, the incidence of neurological complications after pediatric liver transplantation was 8% - 46% . So it is necessary to research the neurological complications and brain protection strategy .Previous studies have studied that some anaesthetic have uncertain affect on the development of children.

Enrollment: 60 estimated patients

Sex: All

Ages: 4 to 12 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children with end-stage liver disease Children with biliary atresia

Exclusion criteria

• pre-existing cerebral disease second liver transplantation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

sevoflurane

Experimental group

Description:

Sevoflurane is inhalated with 1%-2% after anesthesia induction until end of the surgery.

Treatment:

Drug: Sevoflurane

propofol

Experimental group

Description:

Propofol is injected with 9-15 mg/kg/h after anesthesia induction until end of the surgery.

Treatment:

Drug: Propofol