Analgesia After Knee Arthroscopy :Dexmedetomidine vs Fentanyl

Zagazig University

Status: Completed

Conditions: Analgesia

Treatments: Drug: Fentanyl; Drug: Bupivacain; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT04442906

5355

Details and patient eligibility

About

The aim of this study is to evaluate analgesic effects Bupivacaine, Bupivacaine plus Dexmedetomidine and Bupivacaine plus Fentanyl in relieving pain after knee arthroscopic surgery.

Full description

Forty-five patients ASA I - II aged 21-45 years for elective knee arthroscopy were divided into 3 groups: Group B, BD and BF. Group B received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml saline. Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug).

Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug). The time of first request of analgesia and analgesic effect by VAS during the first 24 hr. postoperatively are recorded.

Enrollment: 45 patients

Sex: All

Ages: 21 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Either sex,
• Age 21-45 years,
• American Society of Anesthesia (ASA) I - II for elective knee arthroscopy.

Exclusion criteria

• The patients with history of hepatic and renal diseases, psychiatric disorders,
• Prolonged intake of (NSAIDS, opioids and tricyclic antidepressant),
• Allergy to study drugs and patient who received analgesics up to 24 hr. before surgery were excluded from this study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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45 participants in 3 patient groups

group B

Active Comparator group

Description:

IGroup B received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml saline

Treatment:

Drug: Bupivacain

group BD

Active Comparator group

Description:

. Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug).

Treatment:

Drug: Bupivacain

Drug: Dexmedetomidine

group BF

Active Comparator group

Description:

Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug).

Treatment:

Drug: Bupivacain

Drug: Fentanyl