Analgesia After Total Knee Arthroplasty

University of Manitoba

Status and phase: Unknown; Phase 4

Conditions: Analgesia

Treatments: Drug: CFNB + Posterior Capsular Injection; Drug: Periarticular Injection

Study type: Interventional

Funder types: Other

Identifiers

NCT00869037

B2008:123

Details and patient eligibility

About

The recovery from knee replacement surgery often involves a significant amount of pain. The best way to prevent/treat this pain is unknown. This study will compare two accepted methods of pain control in order to determine which is superior. The first method involves the injection of a solution containing multiple medications into the knee joint at the time of surgery. The second method involves the placement of a catheter adjacent to the femoral nerve which senses pain from the knee. This catheter is used to deliver local anesthetic which serves to block the transmission of pain signals from the nerve. The catheter will be left in place until 2 days after surgery. This method is combined with injection of local anesthetic in a particular area of the knee joint at the time of surgery. Patients will be followed until 2 days after surgery in order to determine which method is superior. We believe the second method will be deemed superior.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I, II, & III patients
• Elective primary total knee arthroplasty
• Spinal Anesthesia

Exclusion criteria

• Patients refusing consent
• Contraindications to regional anesthesia
• Pre-existing neurological disease
• Allergy/contraindication to drugs used in the study
• Revision knee arthroplasty
• Patients with chronic pain/on narcotics preoperatively
• Pre-existing Rheumatoid Arthritis/Ankylosing Spondylitis
• Alcohol or drug abuse
• Psychiatric disorders
• Inability to use the outcome assessment tools
• Wheel chair or walker dependent for mobilization

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 2 patient groups

Periarticluar Multimodal Technique

Active Comparator group

Treatment:

Drug: Periarticular Injection

CFNB plus Posterior Capsular Injection

Active Comparator group

Treatment:

Drug: CFNB + Posterior Capsular Injection