Analgesia After Video-Assisted Thoracic Surgery

Assiut University

Status and phase: Completed; Phase 2

Conditions: Post Operative Pain

Treatments: Drug: Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine; Drug: Local wound infiltration with isobaric bupivacaine; Drug: Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT05094323

10 2021

Details and patient eligibility

About

Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).

Full description

Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).

Adequate postoperative pain relief is imperative to hasten functional recovery, accelerate discharge from the hospital, and reduce chronic postsurgical pain.

Enrollment: 102 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for uniportal VATS under general anesthesia, ASA status I-III, aged from 18 to 70 years old of both sex.

Exclusion criteria

• Contraindications to regional block
• Pregnancy
• Body mass index (BMI) > 30 Kg/m2
• Psychiatric diseases
• Severe renal, liver, or cardiac dysfunction

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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102 participants in 3 patient groups, including a placebo group

Group I

Active Comparator group

Description:

Patients will receive ultrasound-guided deep serratus anterior plane block.

Treatment:

Drug: Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine

Group II

Active Comparator group

Description:

Patients will receive local wound infiltration (LWI).

Treatment:

Drug: Local wound infiltration with isobaric bupivacaine

Group III

Placebo Comparator group

Description:

Patients will receive ultrasound-guided thoracic paravertebral block.

Treatment:

Drug: Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine