Analgesia aNd caNcer recUrrence Lung cAncer Resection

University of Turin

Status: Completed

Conditions: Recurrence Tumor; Analgesia; Opioid Use, Unspecified; Thoracic Surgery

Treatments: Procedure: Peridural analgesia

Study type: Observational

Funder types: Other

Identifiers

NCT04656769

ANNULAR

Details and patient eligibility

About

The choice of analgesia after cancer surgery may play a role in the onset of recurrence, particularly opioids seem to play a role in the immune system by promoting cancer cell proliferation and migration. Based on this consideration, our aim was to assess the impact of perioperative analgesia's choice on cancer recurrence after curative surgery for Stage I Non-Small Cell Lung Cancer. The investigators retrospectively reviewed the records of patients who underwent lung resection for Stage I NSCLC between January 2005 and December 2012. Patients received analgesia either by peridural (PERI group) or, in case of patient refusal or failure in catheter positioning, intravenous analgesia with opioids (EV group). Follow-up was concluded in August 2019. The five-year cumulative incidence of recurrence and the overall survival were evaluated and adjusted with a propensity score matching methodology.

Enrollment: 382 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 yrs
• Patients who underwent lung resection for Stage I NSCLC between January 2005 and December 2012

Exclusion criteria

• Age<18aa
• Pregnancy
• Day hospital patients

Trial design

382 participants in 2 patient groups

PERI group

Treatment:

Procedure: Peridural analgesia

EV group