Analgesia for Endometrial Scratching

University of Sao Paulo

Status: Completed

Conditions: Infertility; Subfertility

Treatments: Drug: Lorazepam 1 mg; Drug: Ibuprofen 600 mg; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02863614

CAAE: 36622214.5.0000.5440

Details and patient eligibility

About

The aim of this study is to evaluate whether Ibuprofen alone or combined with lorazepam reduce the pain associated with endometrial scratching/injury.

Enrollment: 150 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women aged ≥ 18 years undergoing assisted reproduction (IUI, IVF/ICSI, frozen embryo transfer)
• Being submitted to endometrial scratching/injury with a Pipelle on the first four days of the menstrual cycle.
• Not have performed endometrial scratching in the last 90 days.

Exclusion criteria

• None

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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150 participants in 3 patient groups, including a placebo group

Ibuprofen+Lorazepam

Experimental group

Description:

Oral ibuprofen (600 mg) + lorazepam (1 mg); one hour before endometrial scratching.

Treatment:

Drug: Ibuprofen 600 mg

Drug: Lorazepam 1 mg

Ibuprofen

Active Comparator group

Description:

Oral ibuprofen (600 mg) + Placebo; one hour before endometrial scratching.

Treatment:

Drug: Ibuprofen 600 mg

Drug: Placebo

Placebo

Placebo Comparator group

Description:

Placebo + Placebo; one hour before endometrial scratching.

Treatment:

Drug: Placebo