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Analgesia in Knee Arthroscopic Surgery

A

Assiut University

Status and phase

Completed
Phase 2

Conditions

Postoperative Pain

Treatments

Drug: Dexmedetomidine
Drug: Saline
Drug: Dexamethasone

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Pain relief in knee Arthroscopic Surgery is essential for rapid recovery of function.

Full description

Intra-articular analgesia is useful in reducing patients' postoperative disability. It anticipates and prevents the onset of pain, and helps avoid the need for additional drugs. Usually it is possible to reach good analgesia in the immediate postoperative period by the administration of analgesic drugs. Recently, intra-articular administration of different anaesthetic substances with a local action (e.g. bupivacaine) has been introduced in clinical practice. The aim of the administration of these substances should not be the reduction of postoperative pain, but its prevention.

Enrollment

60 patients

Sex

All

Ages

20 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients scheduled for knee arthroscopy under spinal anaesthesia

Exclusion criteria

  • Diabetes Mellitus
  • Contraindication to spinal anesthesia
  • Patient refusal

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

60 participants in 3 patient groups, including a placebo group

Dexamethasone
Active Comparator group
Description:
patients will receive intra-articular 8 mg dexamethasone added to 18 mL 0.25% bupivacaine into the knee joint.
Treatment:
Drug: Dexamethasone
Dexmedetomidine
Active Comparator group
Description:
patients will receive intra-articular 1ug/kg dexmedetomidine added to 18 mL 0.25% bupivacaine into the knee joint.
Treatment:
Drug: Dexmedetomidine
Control
Placebo Comparator group
Description:
patients will receive intra-articular 18 mL 0.25% bupivacaine and 2mL isotonic saline into the knee joint.
Treatment:
Drug: Saline

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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