Analgesia in Knee Arthroscopic Surgery

Assiut University

Status and phase: Completed; Phase 2

Conditions: Postoperative Pain

Treatments: Drug: Dexmedetomidine; Drug: Saline; Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT02818985

SM2016

Details and patient eligibility

About

Pain relief in knee Arthroscopic Surgery is essential for rapid recovery of function.

Full description

Intra-articular analgesia is useful in reducing patients' postoperative disability. It anticipates and prevents the onset of pain, and helps avoid the need for additional drugs. Usually it is possible to reach good analgesia in the immediate postoperative period by the administration of analgesic drugs. Recently, intra-articular administration of different anaesthetic substances with a local action (e.g. bupivacaine) has been introduced in clinical practice. The aim of the administration of these substances should not be the reduction of postoperative pain, but its prevention.

Enrollment: 60 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for knee arthroscopy under spinal anaesthesia

Exclusion criteria

• Diabetes Mellitus
• Contraindication to spinal anesthesia
• Patient refusal

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 3 patient groups, including a placebo group

Dexamethasone

Active Comparator group

Description:

patients will receive intra-articular 8 mg dexamethasone added to 18 mL 0.25% bupivacaine into the knee joint.

Treatment:

Drug: Dexamethasone

Dexmedetomidine

Active Comparator group

Description:

patients will receive intra-articular 1ug/kg dexmedetomidine added to 18 mL 0.25% bupivacaine into the knee joint.

Treatment:

Drug: Dexmedetomidine

Control

Placebo Comparator group

Description:

patients will receive intra-articular 18 mL 0.25% bupivacaine and 2mL isotonic saline into the knee joint.

Treatment:

Drug: Saline