Analgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block

Mansoura University

Status: Completed

Conditions: Colorectal Cancer

Treatments: Other: Quadratus lumborum block; Drug: Atracurium Injectable Product; Drug: Anesthesia Maintenance; Drug: Propofol; Drug: Muscle Relaxation; Drug: Fentanyl NCS; Other: Endotracheal intubation; Other: Erector spinae plane block

Study type: Interventional

Funder types: Other

Identifiers

NCT03803267

MD.18.11.106

Details and patient eligibility

About

Colorectal cancer is the third most common cancer worldwide. These patients usually undergo open surgical resection of cancer under general anaesthesia.

The aim of this study is to detect whether the Erector spinae plan block or Quadratus lumborum block will provide the most ideal analgesia for these patients. Erector spinae plan block is a novel analgesic technique that provides both visceral and somatic analgesia due to its communication with the paravertebral space. Quadratus lumborum block is a truncal nerve block usually used for intra-abdominal surgeries. Ultrasound guidance increases the accuracy and safety of both techniques. A local anaesthetic mixture of Bupivacaine 0.25% and dexamethasone will be used for both techniques.

Full description

Erector spinae plane block and quadratus lumborum block are analgesic techniques suitable for open colorectal cancer surgeries. postoperative pain score, serum levels of biomarkers of stress (cortisol and CRP), primary hemodynamics, time to first rescue analgesic request, the total amount of rescue analgesic consumption and postoperative nausea and vomiting are the parameters of comparison between both techniques.

Enrollment: 68 patients

Sex: All

Ages: 40 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status I or II
• Body mass index from 18.5 to 35 Kg/m2

Exclusion criteria

• Body mass index more than 35 Kg/m2.
• Severe or uncompensated cardiovascular disease.
• Severe renal disease.
• Severe hepatic disease.
• Severe endocrinal disease.
• Pregnancy.
• Postpartum.
• Lactating females
• Allergy to one of the agents used.
• Refusal to participate in the study.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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68 participants in 2 patient groups

Erector spinae plane block

Active Comparator group

Description:

Patients will receive bilateral ultrasound-guided erector spinae plane block as an adjuvant analgesic technique

Treatment:

Other: Endotracheal intubation

Other: Erector spinae plane block

Drug: Anesthesia Maintenance

Drug: Muscle Relaxation

Drug: Fentanyl NCS

Drug: Atracurium Injectable Product

Drug: Propofol

Quadratus lumborum block

Active Comparator group

Description:

Patients will receive bilateral ultrasound-guided quadratus lumborum block as an adjuvant analgesic technique

Treatment:

Other: Endotracheal intubation

Drug: Anesthesia Maintenance

Other: Quadratus lumborum block

Drug: Muscle Relaxation

Drug: Fentanyl NCS

Drug: Atracurium Injectable Product

Drug: Propofol