Analgesic Effect Of Intra-articular Bupivacaine Fentanyl for Postoperative Pain Relief in Knee Arthroscopic Surgery

Mansoura University

Status: Completed

Conditions: Knee Arthroscopic Surgery

Treatments: Drug: Group DB/Dexamethasone-Bupivacaine; Drug: Group FB /Fentanyl-Bupivacaine; Drug: Group PB/Placebo-Bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT03847792

MS/18.09.306

Details and patient eligibility

About

However, local anesthetic agents can produce analgesia for a limited time when used as a single injection. Bupivacaine is a local anesthetic that has an immediate action on pain by blocking peripheral afferents. However, as the ideal analgesic, the drug must cover the whole postoperative period (≥ 24 hours); therefore, bupivacaine is usually combined with many adjutants to provide long-lasting post-arthroscopy analgesia.

Full description

Intr-articular drug administration has gained popularity because of its simplicity and efficacy in achieving anesthesia for diagnostic and operative arthroscopy and for providing postoperative analgesia .although the knee joint has been examined most commonly, arthroscopy of other joints such as shoulder, ankle, wrist, metatarsophalangeal and temporomandibular joints is being increasingly used.

Intra-articular installation of local anesthesia during arthroscopic procedures has been used by many orthopedic surgeons to provide pain relief after surgery.The aim of this study was to evaluate the analgesic efficacy of intra-articular dexamethasone versus fentanyl added as an adjuvant to bupivacaine in patients undergoing knee arthroscopic surgery

Enrollment: 87 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status (ASA) I or II

Exclusion criteria

• Contraindication to spinal anesthesia.
• Allergy to the study drugs.
• Refusal of the patients.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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87 participants in 3 patient groups, including a placebo group

Group DB/Dexamethasone-Bupivacaine

Active Comparator group

Description:

Patients were received an intra-articular injection of 8mg dexamethasone added to18mL of 0.25% bupivacaine

Treatment:

Drug: Group DB/Dexamethasone-Bupivacaine

Group FB /Fentanyl-Bupivacaine

Active Comparator group

Description:

Patients were received an intra-articular injection of 1 ug/kg fentanyl added to 18 mL of 0.25% bupivacaine

Treatment:

Drug: Group FB /Fentanyl-Bupivacaine

Group PB/Placebo-Bupivacaine

Placebo Comparator group

Description:

Patients were received an intra-articular injection of 2 mL isotonic saline added to 18 mL of 0.25% bupivacaine

Treatment:

Drug: Group PB/Placebo-Bupivacaine