Analgesic Effect of Peripheral Cutaneous Nerve Block of Knee Joint After Total Knee Arthroplasty

Diwuweilong

Status: Enrolling

Conditions: Arthroplasty, Replacement, Knee; Analgesia

Treatments: Procedure: New local anesthesia injection site and new local anesthetic drug formulation.

Study type: Interventional

Funder types: Other

Identifiers

NCT05202730

KY20212115-F-2

Details and patient eligibility

About

Local anesthesia was performed on patients with total knee arthroplasty (TKA) through two different injection sites of local anesthetics and two local anesthetic drug . The pain score of patients after TKA was collected, then the analgesic effect of patients after TKA through two different injection sites and two different local anesthetic drug were analyzed and evaluated.

Enrollment: 120 estimated patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Patients between the ages of 40-75, who meet the indications for total knee arthroplasty(TKA) surgery, plan to undergo unilateral TKA surgery, can tolerate surgical trauma, and have no surgical contraindications;
• 2. Patients who have good medical obedience and can cooperate to complete the evaluation of various indicators after the operation and continue to receive follow-up;
• 3. There is no contraindications to combined spinal-epidural anesthesia;
• 4. Agree to accept this trial and sign an informed consent form.

Exclusion criteria

• 1. Allergic to test drugs;
• 2. Abnormal liver, kidney or heart function;
• 3. People who have chronic pain symptoms in other parts of the body other than the knee joint;
• 4. Patients with a history of multiple operations on the knee joint, or patients with abnormal anatomical structures;
• 5. Patients who cannot perform early functional exercise after unconventional knee replacement or other systemic diseases;
• 6. Cannot communicate with researchers normally.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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120 participants in 4 patient groups

Traditional injection site and traditional local anesthetic formulation

Other group

Treatment:

Procedure: New local anesthesia injection site and new local anesthetic drug formulation.

Traditional injection site and new local anesthetic formulation

Experimental group

Treatment:

Procedure: New local anesthesia injection site and new local anesthetic drug formulation.

New injection site and traditional local anesthetic formulation

Experimental group

Treatment:

Procedure: New local anesthesia injection site and new local anesthetic drug formulation.

New injection site and new local anesthetic formulation

Experimental group

Treatment:

Procedure: New local anesthesia injection site and new local anesthetic drug formulation.