Analgesic Effect of Quadratus Lumborum Block in Laparoscopic Hemicolectomy

Petrovsky National Research Centre of Surgery

Status: Unknown

Conditions: Post Operative Pain

Treatments: Procedure: Quadratus lumborum block

Study type: Interventional

Funder types: Other

Identifiers

NCT04848363

BEK25011994

Details and patient eligibility

About

Comparison of the effectiveness: Quadratus lumborum (QL) block by levobupivacaine with placebo.

Full description

All patients will receive standard anaesthesia using fentanyl, protocol, cisatracurium and sevoflurane. Prevention of nausea and vomiting is performing using Apfel score.

All patients will receive post operative multimodal analgesia using paracetamol, ketoprofen, tramadol, and trimeperidine if numerical rating scale > 3 The study assumes use of QL block by levobupivacaine.in comparison with placebo in order to demonstrate the effectiveness of QL block during the operation.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who have undergone left-sided or right-sided laparoscopic hemicolectomy.
• Patient's willingness and ability to sign an informed consent document

Exclusion criteria

• Allergy to local anesthetics
• Chronic pain syndrome and associated opioid use.
• Coagulopathy
• Uncontrolled diabetes mellitus
• Physical Status Classification System scale above 3
• Diseases associated with the pathology of the hypothalamus
• Diseases associated with the pathology of the pituitary gland
• Diseases associated with the pathology of the adrenal glands

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups, including a placebo group

Study group

Experimental group

Description:

patients receiving general anesthesia with propofol, fentanyl and cisatracurium for induction and sevoflurane, fentanyl and cisatracurium for maintaining anesthesia. Patients receiving postoperative multimodal intravenous analgesia with paracetamol, ketoprofen, tramadol, and trimeperidine. In this group, after induction of anesthesia before the operation, bilateral blockade of the square dorsi muscle is performed under ultrasound guidance using 20 ml of a solution of levobupivacaine 2.5 mg / ml.

Treatment:

Procedure: Quadratus lumborum block

Control group

Placebo Comparator group

Description:

patients receiving general anesthesia with propofol, fentanyl and cisatracurium for induction and sevoflurane, fentanyl and cisatracurium for maintaining anesthesia. Patients receiving postoperative multimodal intravenous analgesia with paracetamol, ketoprofen, tramadol, and trimeperidine. In this group, after induction of anesthesia before surgery, bilateral blockade of the square dorsi muscle is performed under ultrasound guidance using 20 ml of saline.

Treatment:

Procedure: Quadratus lumborum block