Analgesic Effect of Resistance Training for Breast Cancer Survivors ((ANTRAC))

Aalborg University

Status: Completed

Conditions: Radiotherapy Side Effect; Chemotherapy Effect; Breast Cancer; Surgery; Pain, Chronic

Treatments: Other: Training; Other: Control

Study type: Interventional

Funder types: Other

Identifiers

NCT04509284

N-20180090

R204-A12469 (Other Grant/Funding Number)

Details and patient eligibility

About

Persistent pain after treatment for breast cancer is a major clinical problem, affecting 25-60 % of the patients and is a source of considerable physical disability and psychological distress. Thus, the development of novel interventions to improve pain management for these patients is of clinical importance. Resistance training (RT) is a promising tool to combat a variety of undesirable adverse effects due to breast cancer treatment. Further, research suggests that it may also be able to provide pain-relieving benefits.

Hypothesis: Resistance training will improve pain perception and physical function in the short- and long term compared to a non-training control group.

Full description

Breast cancer is the most common cancer in women worldwide with more than a million new cases diagnosed every year [1]. Fortunately, due to better treatment options, the population of long-term survivors is increasing. This poses new demands for knowledge on how to manage late effects to the treatment regimen. Persistent pain after treatment for breast cancer is a common and underestimated problem as well as it can be a source of considerable physical disability and psychological distress [2]. Hence, the development of novel interventions to improve pain management is of high clinical relevance. Resistance training (RT) is a promising clinical therapeutic tool to improve a variety of adverse effects to breast cancer treatment [3] and may provide several pain-relieving benefits [4]. However, the efficacy of this modality for managing persistent pain after breast cancer treatment is currently unclear. Therefore, the purpose of this project is to investigate if individualized RT can modulate persistent pain after breast cancer treatment, thereby improving our understanding of how this modality may benefit patients and contribute to clinical guidelines for pain management in this clinical population.

Enrollment: 20 patients

Sex: Female

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• primary diagnosis of breast cancer (grades I-IIIA).
• adult women at least 18 years of age.
• having received breast cancer treatment (i.e. surgery and possible adjuvant chemo and/or radiotherapy) at least 18 months before the start of the study.
• self reported pain in the areas of the breast, shoulder, axilla, arm and/or side of body with an intensity of ≥ 3 on a numeric rating scale (0 = no pain, 10 = worst pain imaginable).
• no signs of cancer recurrence.
• reading, writing and speaking Danish.

Exclusion criteria

• breast surgery for cosmetic reasons or prophylactic mastectomy.
• bilateral breast cancer.
• lymphedema.
• other chronic pain conditions (e.g., rheumatoid arthritis).
• previous diagnosis of fibromyalgia syndrome.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Training

Experimental group

Description:

Participants with persistent pain after breast cancer treatment will receive 24 sessions of individualized progressive total body resistance training, supervised by a certified strength and conditioning specialist.

Treatment:

Other: Training

Control

Other group

Description:

Participants with persistent pain after breast cancer treatment will be instructed to continue their everyday lifestyle and be encouraged not to engage in new forms of exercise or physical activity throughout the study period.

Treatment:

Other: Control