Analgesic Efficacy of External Oblique Intercostal Block vs Subcostal Transversus Abdominis Plane Block in Open Surgical Nephrectomy

Cairo University (CU)

Status: Enrolling

Conditions: Subcostal Transversus Abdominis Plane Block; Analgesic Efficacy; Open; Nephrectomy; External Oblique Intercostal Block

Treatments: Drug: Control group; Drug: External Oblique Intercostal Plane Block; Drug: Transversus abdominis plane block

Study type: Interventional

Funder types: Other

Identifiers

NCT06584695

AP2407-201-013

Details and patient eligibility

About

To compare the efficacy of unilateral ultrasound-guided oblique subcostal transversus abdominis plane block with unilateral ultrasound-guided external oblique intercostal plane block in providing intraoperative and postoperative analgesia in cancer patients undergoing open nephrectomy.

Full description

Open surgery remains one of the procedures used for those patients requiring partial or radical nephrectomy and is associated with a high incidence of severe immediate postoperative pain and chronic pain the months following surgery.

Regional anesthesia techniques are frequently recommended for pain control in open nephrectomy as they decrease the need for parenteral opioid and improve patient satisfaction.

Although abdominal wall blocks are known to decrease opioid requirements without causing epidural associated hypotension, their role in flank surgeries has been less well-established. The dermatomes that need to be covered in flank incision are T9 to T11.

Studies have confirmed that ultrasound-guided (USG) transversus abdominis plane (TAP) block is an effective method of analgesia for upper abdominal surgeries, lower abdominal surgeries and kidney transplantation with minimal side effects.

The external oblique intercostal (EOI) block is a novel method providing simple and effective somatic analgesia to the upper abdomen with minimal side effects. Other advantages include easy sonoanatomy (even in obese patients), being performed in the supine position, and no anticoagulation concern

Enrollment: 63 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age (18-65) year.
• Both sexes.
• American Society of Anesthesiologists (ASA) class II and III.
• Cancer patients candidate for open nephrectomy .

Exclusion criteria

• Patient refusal.
• Skin lesions or infection at the site of proposed needle insertion.
• Cognitive disorders.
• History of psychiatric disorders or drug abuse.
• Patients allergic to medication used.
• ASA class IV.
• Coagulopathy.
• Body mass index (BMI) more than 35.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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63 participants in 3 patient groups

Transversus abdominis plane group

Experimental group

Description:

patients will receive unilateral ultrasound-guided oblique subcostal transversus abdominis plane block block

Treatment:

Drug: Transversus abdominis plane block

External oblique intercostal group

Experimental group

Description:

Patients will receive unilateral ultrasound-guided external oblique intercostal block

Treatment:

Drug: External Oblique Intercostal Plane Block

Control group

Active Comparator group

Description:

Patients will receive IV morphine 0.1mg/kg after induction of general anesthesia.

Treatment:

Drug: Control group