Analgesic Efficacy of Intravenous Lidocaine and/or Ketamine

Lausanne University Hospital (CHUV)

Status: Completed

Conditions: Postoperative Pain

Treatments: Drug: association ketamine-lidocaine; Drug: Lidocaine,; Drug: Ketamine; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01439399

KL-48h

179/05 (Other Identifier)

Details and patient eligibility

About

The aim of the present study is to evaluate the analgesic benefit of intravenous lidocaine and ketamine in the perioperative period of abdominal surgery.

Full description

Optimal postoperative pain management facilitates rehabilitation immediately after abdominal surgery. Multiple studies have demonstrated that successful postoperative analgesia also reduces perioperative complications and improves patient comfort, thereby providing many benefits for the patient. In acute postoperative pain management intravenous lidocaine and/or ketamine have been advocated because of their morphine-sparing effect.

Enrollment: 52 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• abdominal surgery by laparotomy

Exclusion criteria

• laparoscopy
• history of chronic pain
• opioid self-administration
• psychiatric disorders
• difficulties with communication
• renal or hepatic dysfunction
• ASA physical status > 3

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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52 participants in 4 patient groups, including a placebo group

Lidocaine

Active Comparator group

Description:

Intravenous lidocaine administered preoperatively (anesthesia induction) and postoperatively during 48 hours

Treatment:

Drug: Lidocaine,

Ketamine

Active Comparator group

Description:

Intravenous ketamine administered preoperatively (anesthesia induction) and postoperatively during 48 hours

Treatment:

Drug: Ketamine

Ketamine-Lidocaine

Active Comparator group

Description:

Intravenous association of ketamine and lidocaine administered preoperatively (at anesthesia induction) and postoperatively during 48 hours.

Treatment:

Drug: association ketamine-lidocaine

Saline 0,9%

Placebo Comparator group

Description:

Control group

Treatment:

Drug: Placebo